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The metabolic pathways and corresponding enzymes are organized around the TCA cycle at the center, branching out to include amino acid metabolism, purine metabolism, and the glutathione cycle, highlighting the interconnectivity and complex response to the oxidative stress induced by the absence of GR

Working within cells, it helps preserve stability across systems that contribute to healthy aging and overall physiological balance

[DOI] [Google Scholar] 29.Arji E.E., Eze U.J., Ezenwaka G.O., Kennedy N

In contrast, a study by Sangeet et al

Epithelial HIF2 expression induces intestinal barrier dysfunction and exacerbation of arthritis