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How GLP-1 Receptor Agonists Cause Weight Loss By binding to the GLP-1 receptor, GLP-1 RAs mimic the effects of having eaten and released GLP-1

This approach emphasizes consistency and transparency over promotional claims

First, the stepwise increase in weight loss as additional receptor mechanisms are added (GLP-1 only to GLP-1+GIP to GLP-1+GIP+glucagon) is consistent with the additive-mechanism hypothesis that underpinned the retatrutide program