2 Mechanism of ferroptosis in BC The regulation of ferroptosis is primarily governed by three essential components: reactive oxygen species (ROS), the interaction between glutathione (GSH), ROS facilitated by Glutathione Peroxidase 4 (GPX4), and the induction of lipid peroxidation catalyzed by arachidonic acid lipoxygenase (ALOX) (Sui et al., 2022)
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Experimental feature sets include the first 5, 14, 30, or 50 CCLE transcriptomics PCs which are selected to capture 93%, 95%, 97%, or 98% of the variance, respectively (Supp