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doi: 10.1186/s41043-024-00516-4

Further, targeted metabolomics results revealed that GGCT knockdown markedly attenuated TCA cycle flux, decreasing key intermediates including pyruvate, succinate and fumarate (Fig

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Peripheral Metabolic Effects Beyond glucose regulation, GLP2 influences multiple metabolic parameters: Improved insulin sensitivity markers including HOMA2-IR reductions Favorable effects on lipid profiles with reductions in triglycerides and LDL cholesterol Decreased liver enzyme levels suggesting hepatic metabolic improvements Increased insulin-like growth factor binding proteins (IGFBP1 and IGFBP2) [CALLOUT BOX Highlighted] Key Mechanistic Insight: GLP2s imbalanced dual agonism stronger GIP receptor activation combined with biased GLP-1 receptor signaling creates a unique pharmacological profile distinct from selective GLP-1 receptor agonists

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