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Cysteine residues in Keap1 act as sensors for electrophiles and oxidants, and their oxidation leads to the release and subsequent translocation of Nrf2 into the nucleus where it can bind to the ARE4 sequence in the promoter region of genes involved in antioxidant defense (Moinova and Mulcahy 1999)

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Hur GH, Han SC, Ryu AR, Eom Y, Kim JW, & Lee MY

For example, if you look on Clinicaltrials.gov, there are only two studies that even mention BPC-157, says Cushman

Always reseal the container tightly after each use