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NNMT is overexpressed in select tissues (e.g., adipose tissue, skeletal muscle, etc.) in pathophysiological conditions, making it a clinically relevant target for drug development in several chronic diseases including obesity and diabetes

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10.1038/254667a0 24 JonesD

NNMT (Nicotinamide N-Methyltransferase) is a cytosolic enzyme that catalyses the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide producing 1-methylnicotinamide (1-MNA) and S-adenosyl-homocysteine (SAH) as reaction products

That is a statistically significant difference, but the magnitude of weight loss is modest by any standard