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Individuals with a history of severe allergic reactions to injectable vitamins should be monitored closely or offered alternatives per clinician judgment
Redner A, Andreeff M , Miller DR, Steinherz P, Melamed M
A 2014 review (PMID 25098945) reported positive copper patch-test reactions in a weighted average of about 3.8% of tested subjects, and earlier work on the dermatologic aspects of copper hypersensitivity (PMID 15327478) similarly described it as infrequent but real in selected cases
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The increase in the production of glutathione and other detoxification enzymes may result in the liberation of these from the body resulting in symptoms
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