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These modifications establish an IUB288 half-life of approximately 6.3 hrs, with optimized attributes of enhanced solution stability, solubility, and retention of receptor specificity [76]

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The primary outcomes are the change in reverse transcriptase activity in blood and CSF and the penetration of lamivudine across the blood brain barrier as reflected in the plasma/CSF ratio of 3TC 5-triphosphate (NCT04552795)

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