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The investigators attributed the angiogenic effect to upregulation of vascular endothelial growth factor receptor 2 (VEGFR2) and activation of the Aktendothelial nitric oxide synthase (eNOS) signaling pathway
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However, these injections can be painful and may cause adverse events such as infections and bruises, making self-administration challenging for elderly patients
The solution must be aliquoted into single-use portions before freezing
This has practical implications
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