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Sullivan JA, Grummer MA, Yi FX, Bird IM: Pregnancy-enhanced endothelial nitric oxide synthase (eNOS) activation in uterine artery endothelial cells shows altered sensitivity to Ca2+, U0126, and wortmannin but not LY294002evidence that pregnancy adaptation of eNOS activation occurs at multiple levels of cell signaling

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It was found that there was an increased predisposition to develop glucose intolerance or T2D, and that this change was independent from IGFBP-1 [208]

Another study found increased skin thickness in participants between the ages of 45 to 59

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