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Their predictive value for gallstone disease is very low since they often occur with functional dyspepsia, gastroesophageal reflux disease, irritable, bowel syndrome, or cardiac disease [96,97,98,99], and can persist after cholecystectomy [13]
Moreover, accessibility issues may arise for individuals in remote areas or those with limited mobility, making regular injections less feasible
After menopause, estrogen production occurs not from the ovaries but at peripheral adipose tissue sites, where estrone is produced [10, 21, 22]
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