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The remaining authors declare that they have no conflict of interest

If approved, orforglipron would offer an alternative to another GLP-1 pill, Rybelsus (semaglutide)

Activation of these receptor systems allows investigation of several interconnected physiological processes

Compression garments (20-30 mmHg or higher) provide mechanical support and help control swelling, though patient adherence can be challenging due to discomfort and difficulty with application