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The choice between them is driven by cardiovascular risk profile, kidney function, cost, and availability rather than weight loss difference

Mechanistically, butyrate inhibits mTORC1, attenuates eIF2ATF4-dependent ISR signaling, and represses DGAT/ACSL-dependent LD biogenesis, whereas microglial Rptor overexpression abolishes these protective effects, identifying mTORC1 as an upstream metabolic checkpoint

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This, in turn, triggers the HIF1A (hypoxia inducible factor 1 subunit alpha)-dependent Warburg effect and AIM2 (absent in melanoma 2)-dependent inflammasome activation, contributing to Kras G12D -induced pancreatic tumorigenesis [212]