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The original nomogram line separating possible toxicity from unlikely toxicity was based on a 4-hour acetaminophen concentration of 200 micrograms/mL (1300 micromoles/L), but was subsequently modified by moving the line to a 4-hour acetaminophen concentration of 150 micrograms/mL (1000 micromoles/L) to increase the safety margin for treatment decisions

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Caron P, Grunenwald S, Persani L, Borson-Chazot F, Leroy R, Duntas L