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These reactive species can damage DNA, proteins, and lipids, thereby contributing to genomic instability and tumor development [95]

Treatment of Gallstone Complications In patients with gallstones in the common bile duct (choledocholithiasis), stone removal through a combination procedure called endoscopic retrograde cholangiopancreatography (ERCP) with biliary sphincterotomy (cutting of the muscular sphincter that controls bile flow into the small intestine) is considered the best option and is the most commonly used approach

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Funding: This work was supported by a NIH grant AI 15122 ( The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript