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doi.org/10.1210/clinem/dgad463 Mostajeran F, Tehrani HG, Rahbary B

During this period, its glucose-lowering and appetite-suppressing effects gradually diminish

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The underlying mechanisms involve alterations in intestinal permeability, abnormal microbial metabolites, the actions of neuroactive compounds, and regulation via the immune mediated MGBA

Included studies comprised original clinical research (cross-sectional analyses, cohort studies, and randomized controlled trials), experimental animal investigations, and mechanistic studies specifically addressing carnitine metabolism in DKD