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Andrew: For those that are listening to this and they may recall, I did an episode of this podcast with Dr
In September 2025, clinical research was published on weight loss for two oral incretin therapies: an oral version of semaglutide and Orforglipron, also a GLP-1 receptor agonist
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Retatrutide significantly reduced body weight (mean difference [MD]: 14.33%), body mass index (MD: 5.38), waist circumference (MD: 10.51 cm), fasting plasma glucose (MD: 23.51 mg/dL), hemoglobin A1c (MD: 0.91%), and systolic and diastolic blood pressure (MD: 9.88 mm Hg and 3.88 mm Hg, respectively), all with P values 35 kg/m 2 , frequently resulting in diabetes remission and improvement in associated obesity-related conditions
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