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These longer cycles require more careful monitoring and may benefit from slight dose reductions in weeks 13-16 to maintain receptor sensitivity

User 20 ran three separate 8-week cycles for De Quervain's tendinitis, suggesting that repeat cycles are used when conditions respond partially but do not fully resolve

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The preclinical evidence compiled in animal models, however, offers a highly dependable, reproducible dataset demonstrating accelerated soft tissue remodeling, localized capillary formation, and cellular matrix organization