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These include modulation of pathways involved in inflammation, oxidative stress, epigenetics, mitochondrial dysfunction, the gut microbiota, tryptophankynurenine metabolism, the HPA axis, neurogenesis and BDNF, epigenetics, and obesity

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doi:10.1016/s0091-6749(03)00010-1 16 Garcia-MaurioSGonzalez-HabaMGCalvoJRRafii-El-IdrissiMSanchez-MargaletVGobernaRet al

Among a cohort of more than 2.1 million patients with type 2 diabetes (mean age 68 years

These considerations highlight the need for future studies specifically designed to evaluate GLP-1RAs in patients at high risk of PsA, particularly those with subclinical inflammation or early musculoskeletal symptoms