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In rare cases, GLP-1 agonists like Ozempic have been linked with eye problems, gallbladder and pancreas problems, blocked intestines, and stomach paralysis (a condition in which your stomach muscles don't contract as they should to help you digest food)

In particular, preclinical studies have demonstrated that GLP-1 and its more stable and long-lasting analogues GLP-1RAs possess neuroprotective and antiapoptotic properties, modulate long-term potentiation and synaptic plasticity, as well as promote the differentiation of neuron precursors, and can reduce depressive behavior [75]

doi: 10.2337/db21-0848 Summary Keywords GLP-1 - glucagon-like peptide-1, GIP - glucose-dependent insulinotropic peptide, obesity, incretin, pharmacology Citation Douros JD, Flak JN and Knerr PJ (2025) The agony and the efficacy: central mechanisms of GLP-1 induced adverse events and their mitigation by GIP

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