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It is one of the most complex nutrient absorption pathways in the human body, and semaglutide interferes with it at multiple points simultaneously

Procedural factors include those which add to the risk of aspiration by increasing the potential for nausea/vomiting or nasogastric secretions

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The persistently elevated risk amongst these trial populations demonstrates the limitations of current management strategies and highlights the need for therapies that address the link between metabolic disease and direct cardiovascular pathology