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A 2023 systematic review concluded that GLP-1 RA use in patients with heart failure and reduced ejection fraction warrants caution due to potential risk of worsening heart failure events and arrhythmias

Reduced levels of ascorbate have been found in patients with viral infections ( Vitamin C has improved survival in different murine models of lethal infection

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Some individuals achieve target weight loss effects at lower doses, while others require gradual escalation to reach their therapeutic window

Underdosing can cause a return of appetite, withdrawal-like symptoms , and stalled progress