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The commenter recommended that CMS consider a volume threshold of 500 single major claims (or the existing greater or equal to 99 claims that constitute greater than or equal to the 2 percent criterion) as the standard for designating an item or service significant for purposes of the 2 times rule

Increased erythrocyte oxidative stress results in the opening of multiple ion channels, comprising the nonselective cation channels (NSCC), like sodium, potassium, and calcium channels [202, 404]

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Recent studies on the cellular composition of human and mouse tissue showed that endothelial cells are the most abundant cells in the heartabout 60 percent thus implying to have an important role in heart physiology and pathology 5

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