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With the duration of your prescription being on average around 40 weeks, you will notice at the end that you have lost between 5.9% to 10.9% of your total body weight, which depending on your starting weight can be around 14 lbs or more

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Maintaining adequate hydration is one of the main safety precautions for preventing any kidney problems

Here is a quick patient selection matrix to guide the discussion with your healthcare provider: Sources & References NCBI StatPearls Semaglutide AJMC PIONEER Clinical Trial Program Overview PubMed PIONEER 1 Trial ADA DPP/DPPOS Metformin Weight Loss Study ADA Standards of Care in Diabetes 2025 ADA Prevention or Delay of Diabetes (Standards 2025) GoodRx Rybelsus Cost Without Insurance Novo Nordisk PIONEER PLUS Trial Results Disclaimer: This information is intended for general knowledge and informational purposes only and does not constitute medical advice

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