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The peptide agonist retains an -helical conformation as it sits deep within the receptor-binding pocket

Increased Energy Expenditure: Activation of the glucagon receptor encourages the body to break down stored fat and increases the metabolic rate, further supporting weight loss

It is a direct brake on the central inflammatory cascade that drives autoimmune damage

It is important to note that tirzepatide comes with a boxed warning for the risk of thyroid C-cell tumors, and may delay gastric emptying, which could affect the oral absorption of other medications