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Understanding the Innate Repair Receptor (IRR) The innate repair receptor is a heteromeric receptor complex composed of: Erythropoietin receptor (EPOR) -common receptor (CD131) This receptor is activated in response to: Tissue injury Hypoxia Inflammation Oxidative stress Activation of the IRR triggers a cascade of protective signaling designed to: Limit tissue damage Reduce inflammation Promote cellular survival Support repair rather than scarring ARA-290 was designed specifically to activate this receptor without activating erythropoiesis

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(41) observed that the majority of the investigated genes in human leukocytes had recovered 24 h after an induced inflammatory challenge

Practical Wisdom What Tuell and colleagues leave us with is more than data points it is a roadmap for resilience