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In the STEP UP clinical trial, participants on the highest dose of Wegovy (7.2mg) lost an average of 20.7% of their body weight over 72 weeks 2
But neither compensates for sloppy fundamentals
Several cross-sectional and prospective cohort studies have reported that men with poorly controlled diabetes (as reflected by elevated Glycated Hemoglobin A1c (HbA1c) levels) exhibit significantly lower sperm concentration, reduced motility, and higher rates of sperm DNA fragmentation [10, 300]
ER transcriptionally promotes the expression of SLC7A11 and SLC3A2 Given the observed association between ER and SLC7A11/SLC3A2 expression, we investigated how ER may regulate the expression SLC7A11 and SLC3A2
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