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DPP4 inhibitors and risk of infections: a metaanalysis of randomized controlled trials

In a combined fertility and prenatal and postnatal study with insulin glargine in male and female rats at subcutaneous doses up to 0.36 mg/kg/day, which was approximately 2-times the recommended human subcutaneous maximum dose of 60 units/day (0.0364 mg/kg/day), based on mg/m2, maternal toxicity due to dose-dependent hypoglycemia, including some deaths, was observed

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Additional methods were provided in the Supplementary Methods

[1] [2] Marketed under the brand names Mounjaro (for diabetes) and Zepbound (for weight loss), tirzepatide represents a novel class of medications known as dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonists