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After mechanical damage to the brain (secondary injury), the release of excitatory amino acids such as glutamate causes excessive stimulation of the N-methyl-D-aspartate (NMDA) receptor

Combined with GO network analysis, the Molecular Complex Detection (MCODE) algorithm was then applied to this network to identify neighborhoods where proteins were densely connected

A previous review by de Almeida and colleagues has highlighted CBD binding on a subset of G-protein-coupled receptors and ion channels (Almeida and Devi 2020)

Repetitive exercise such as running and cycling can aggravate a bursa (fluid filled sac)which lies between this bone and tendon creating inflammation