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Vegans and vegetarians can consider B12 supplements or fortified foods to bridge the nutritional gap

The evidence indicates their doses are therapeutically effective

In late-stage trials, people taking orforglipron lost an average of about 12% of their body weight over roughly 72 weeks , and head-to-head studies suggest it may outperform standard oral semaglutide tablets (Rybelsus) in both weight loss and blood sugar control

Misuse can lead to serious risks, including copper toxicity or adverse effects like angiogenesis, which may be dangerous in cases of cancer