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Tirzepatide, a newer GLP-1/GIP receptor agonist, activates two separate appetite pathways rather than one, making it effective for patients who've stopped responding to single-agent GLP-1 therapy

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The most frequent adverse events in the lenvatinib group were hypertension (67.8%), diarrhea (59.4%), fatigue (59%), decreased appetite (50.2%), decreased weight (46.4%), and nausea (41%)