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In contrast, in the chronic phase this adaptative response is impaired, leading to a vicious circle, as inactivation of GPx causes additional oxidative stress

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12 Of particular interest, a 20-week research trial involving nondiabetic patients with a mean body mass index of 30 to 40 kg/m 2 at baseline compared the weight loss effects of liraglutide versus orlistat 120 mg three times daily or placebo

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