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A modest increase in resting heart rate was also observed in some participants receiving higher doses, which is an anticipated effect of glucagon receptor agonism and warrants ongoing monitoring in future trials

With several effective options available, the choice is less about whether to take a medication and more about which one is the best fit for someone

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Moreover, in the SNI-induced chronic neuropathic pain model, heat hyperalgesia was alleviated in mice challenged with SNI and administered intraperitoneal injections of 50 g of exendin 2029, with effects observed as early as 1 hour postadministration and peaking at 2 hours compared with those in the vehicle-administered group (Supplementary Fig

and sweets, carbohydrates, starches, and fast-food fats [145]