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MB can cause a rise in blood pressure and peripheral vascular resistance, and it may reduce regional blood flow (for instance, caution is needed in patients with pulmonary hypertension or compromised circulation because MB could potentially worsen those by opposing NO-mediated vasodilation)

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The loci-specific methylation levels and regulation of Lmx1b, Abcc5, Gpc3, and Cfb genes may play a key role in the treatment of Xiaoyaosan [5, 531]

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