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Thus, unlike these studies performed in OPMDs, the studies investing the efficacy of lycopene on managing gastrointestinal precancerous lesions were predominantly limited to animal studies, observational studies, or cohort studies, RCTs evaluating on its efficacy are needed in the future

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Even though a meta-analysis reported an increase in cardiovascular mortality linked to the use of TZDs in dialysis patients (Nissen and Wolski, 2007), no definitive proof are available on the risk related to this medication in this population