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Delayed gastric emptying may undergo tachyphylaxis, potentially reducing the impact of DDIs with repeated dosing.169,174 Moreover, delayed absorption of the concomitant drug due to delayed gastric emptying can be minimized by administering the drug 1 h before GLP-1 RAs or a dual GLP-1/GIP RA administration.168 However, the possibility of DDIs related to delayed gastric emptying cannot be excluded,175 so investigators recommend monitoring when oral drugs are co-administered with GLP-1 RAs and a dual GLP-1/GIP RA
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Hyperinsulinism/hyperammonemia syndrome in children with regulatory mutations in the inhibitory guanosine triphosphate-binding domain of glutamate dehydrogenase
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It: Pulls in water Ferments Produces gas Slows motility Which feels exactly like bloating
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