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Two studies were in the preprint

Unlike apoptosis, its execution is independent of caspases and is instead driven by receptor-interacting protein kinase 1 (RIPK1) and receptor-interacting protein kinase 3 (RIPK3), with mixed lineage kinase domain-like protein (MLKL) acting as the executioner by oligomerizing and forming pores in the plasma membrane, leading to its rupture (41)

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Slow titration and weekly symptom tracking minimize adverse effects