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Oral formulations were also developed.1,3,5 GLP-1 receptor monoagonists for the treatment of obesity: liraglutide and semaglutide The first molecule to be marketed for the treatment of obesity was liraglutide (LIRA), administered via daily subcutaneous injection, which became available in 2014

It should also be based on access, safety, and whether the medication is actually available through legal and proper channels