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IMQ-induced psoriatic mouse model Six-week-old female BALB/c mice or C57BL/6 mice, along with NRF2 knockout mice (acquired from the Model Animal Research Center of Nanjing University), were randomly grouped and maintained in an SPF environment, subjected to a 12-hour light/dark cycle, and provided with unrestricted access to food and water

[13] [10] Discontinuation rates due to gastrointestinal side effects ranged from 4-7% across clinical trials, indicating that most patients can tolerate the medication with appropriate management strategies

Melatonin reduces night blood pressure in patients with nocturnal hypertension