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Interestingly, one of the most prominent GLP-1R-cholesterol binding sites identified here lies within the functionally important TM5-TM6 region required for G protein signal transduction, indicating the potential impact of cholesterol binding on GLP-1R activation and downstream signalling

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A 2007 study conducted in Russia found that epithalon extended the lifespan of rats exposed to natural and constant illumination [9]

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