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for example, miR-135b-3p directly downregulates GPX4 and exacerbates myocardial ischemiareperfusion injury [132], whereas miR-30d and miR-190a-5p confer protection by targeting pro-ferroptotic enzymes or upregulating ferritin heavy chain [135, 136]

[DOI] [PubMed] [Google Scholar] 123.Otogawa K, Kinoshita K, Fujii H, Sakabe M, Shiga R, Nakatani K, Ikeda K, Nakajima Y, Ikura Y, Ueda M, Arakawa T, Hato F, Kawada N