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Conclusions This study establishes a novel and critical molecular mechanism for the pharmacological actions of BPC157, centered on the BPC157-FBXO22-BACH1 axis

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Experimental studies demonstrate that salidroside can: Increase superoxide dismutase activity Enhance glutathione defenses Reduce lipid peroxidation Suppress NF-B signaling [22] Lower inflammatory cytokine production Protect mitochondrial function Human Evidence and Current Limitations Several clinical studies involving Rhodiola rosea extracts have reported improvements in: Stress-related fatigue Mental performance Burnout symptoms Anxiety scores Mood disturbances Some trials have also observed reductions in subjective stress and improvements in resilience-related outcomes [25]