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Net DA release and net rCBF change DA release was calculated by subtracting the D 2/3 R BPnd in the drug condition (e.g., NAL) from that in the SAL condition and dividing the result by D 2/3 R BPnd in the SAL condition (to normalize for regional differences in D 2/3 R)

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For healthy adults, these effects tend to be temporary and mild, but folks with a history of dehydration, kidney problems, or who participate in weight-class sports should talk with a healthcare professional before adding to your routine