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This imbalance underscores the critical interdependencies within the ETC, where impairment in one complex can propagate through the chain, affecting overall electron transport efficiency

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As experimental evidence, GFAP expression is markedly upregulated in reactive astrocytes during CNS inflammation, a characteristic feature of gliosis observed in AD, resulting in a 1.23.3-fold increase in GFAP levels (Kamphuis et al., 2014)

Tyrosinase the rate-limiting enzyme in melanin biosynthesis is transcribed

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