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Even minor deficiencies in lymphoid cells can have far reaching negative effects on immune function

Dysregulation of GHIGF-1 axis can amplify the synergistic effect of GH and IGF-1 to promote uncontrolled cell proliferation, cell movement, angiogenesis, and suppress apoptosis to increase risk of neoplasia (272)

We're extrapolating from robust data in similar tissue types

doi: 10.1016/j.trsl.2012.05.001 165 AminiLChekiniRNateghiMRHaghaniHJamialahmadiTSathyapalanTet al

The dosing schedules follow the same general principle used across all GLP-1 receptor agonists: start low, escalate gradually, reach a maintenance dose