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Because GH and IGF-1 promote protein synthesis and lipolysis, these hormonal changes provide a plausible mechanistic basis for modest increases in lean body mass, improved recovery and support for fat loss seen in clinical and observational contexts, but robust controlled trials explicitly measuring those endpoints are still lacking

LPS plus IFN- treatment remarkably increased the mRNA levels of Tnf- , Il-6 , Il-1 , iNos and Mcp-1 in BMDMs, whereas 100 M LC reversed the increased levels of the cytokines (Fig