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Intramuscular (IM) B12 injections using hydroxocobalamin, the preferred licensed form in the UK are recommended when: Oral supplementation has failed to correct a documented deficiency The patient has difficulty adhering to daily oral regimens Serum B12 levels remain persistently low despite adequate oral dosing There is clinical evidence of neurological or haematological complications In line with BNF guidance, the standard IM regimen for confirmed deficiency without neurological involvement is a loading course of 1 mg hydroxocobalamin on alternate days for two weeks , followed by maintenance of 1 mg every three months
doi: 10.1177/2515690X211036875 119 HotchkissR
Journal Clinical Pharmacology 56 (6), 635638
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Preventative Care for At-Risk Groups: Vegetarians and Vegans: Plant-based diets can lack sufficient vitamin B12, making supplementation through injections an effective option for maintaining health
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