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It is estimated that 11% of the female population has this condition

In the trial population the efficacy endpoint estimand was used, whereas the treatment regimen estimand was used in the subgroup population (patients with BMI 35 kg/m 2 + prediabetes + high risk of CVD) due to the unavailability of data

DURATION-5: Exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patients with type 2 diabetes

Maintenance Phase (Week 5 and beyond): Once-weekly doses (Weeks 58) Every 2 weeks or as clinically needed thereafter Dose may be 56 mg or 84 mg depending on therapeutic response How Is SPRAVATO Administered

From the perspective of animal experiments, in ApoE / mice expressing human cholesteryl ester transfer protein (hCETP), TMAO derived from L-carnitine levels inversely correlated with aortic lesion size in both the aortic root and thoracic aorta (23)