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SIRT1 targets over 100 different proteins involved in metabolism, stress responses, and longevity pathways, including the tumor suppressor p53, the transcriptional coactivator PGC-1, and the DNA repair protein Ku70. Through deacetylation of PGC-1, SIRT1 promotes mitochondrial biogenesis and oxidative metabolism, while deacetylation of p53 reduces apoptotic responses to mild stress, promoting cellular survival and longevity

If you are on all three medications, monitoring INR more frequently when starting tirzepatide is prudent

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More recent clinical findings have continued to show substantial effects on body weight and glucose measures