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One main thing is dehydration

Tian L, Li X, Ji H, et al

Hansen et al., in their commentary on Humphrey and Lawrences paper [87], emphasized that several studies have demonstrated improvements in quality of life associated with GLP-1 RA-induced weight loss, along with health-related benefits such as enhanced cardiovascular outcomes that outweigh the impact of facial aging

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La sua concentrazione plasmatica diminuisce con l'et: circa 200 ng/ml a 20 anni contro 80 ng/ml a 60 anni, correlato al declino della capacit rigenerativa